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Not unlike the terraced fields of Yuanyang in southern Yunnan, Luoping's canola fields attract many photographers. During this high travel season for the county regular buses leave from Kunming's bus stations on an almost hourly basis.Accommodation in Luoping ranges from cheap 10-yuan boarding houses to more expensive star-rated hotels.A novel series of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were designed, synthesized and biologically evaluated as vinylogous CA-4 analogues, which involved a rigid [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine scaffold to fix the configuration of (Z, E)-butadiene linker of A-ring and B-ring.Among these rigidly vinylogous CA-4 analogues, compounds 4d, 5b, 5i, 6c, 6e, 6g, 6i and 6k showed excellent antiproliferative activities against SGC-7901, A549 and HT-1080 cell lines with IC = 0.009–0.013 µM).Furthermore, 6i potently induced cell cycle arrest at G/M phase in SGC-7901 cells.Competitive binding assays and docking studies suggested that compound 6i binds to the tubulin perfectly at the colchicine binding site.Taken together, these results revealed that 6i may become a promising lead compound for new anticancer drugs discovery.

While clinically applied microtubule targeting drugs binding at the vinca alkaloid or taxanes sites in tubulin are greatly successful, there are no clinically applied colchicine-binding site anticancer drugs currently available.The collection is accompanied by a Commentary article, which provides an authoritative, concise, and accessible point of reference for the most important modes of atmospheric variability.Hold cursor over location to display name; click to go to sources &/or status description (if available, the cursor will show as ; if not, it will show as ).Ela se encontra no Freemasons' Hall, na rua Great Queen Street .O seu título (Quatuor Coronati) significa, em latim, Quatro Coroados, uma referência à lenda dos Quatro Mártires Coroados.

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